Communicating science in the COVID-19 news in the UK during Omicron waves: exploring representations of nature of science with epistemic network analysis

News media plays a vital role in communicating scientific evidence to the public during the COVID-19 pandemic. Such communication is important for convincing the public to follow social distancing guidelines and to respond to health campaigns such as vaccination programmes. However, newspapers were criticised that they focus on the socio-political perspective of science, without explaining the nature of scientific works behind the government’s decisions. This paper examines the connections of the nature of science categories in the COVID-19 era by four local newspapers in the United Kingdom between November 2021 to February 2022. Nature of science refers to different aspects of how science works such as aims, values, methods and social institutions of science. Considering the news media may mediate public information and perception of scientific stories, it is relevant to ask how the various British newspapers covered aspects of science during the pandemic. In the period explored, Omicron variant was initially a variant of concern, and an increasing number of scientific evidence showed that the less severity of this variant might move the country from pandemic to endemic. We explored how news articles communicate public health information by addressing how science works during the period when Omicron variants surge. A novel discourse analysis approach, epistemic network analysis is used to characterise the frequency of connections of categories of the nature of science. The connection between political factors and the professional activities of scientists, as well as that with scientific practices are more apparent in left-populated and centralist outlets than in right-populated news outlets. Among four news outlets across the political spectrum, a left-populated newspaper, the Guardian, is not consistent in representing relations of different aspects of the nature of scientific works across different stages of the public health crisis. Inconsistency of addressing aspects of scientific works and a downplay of the cognitive-epistemic nature of scientific works likely lead to failure in trust and consumption of scientific knowledge by the public in the healthcare crisis

Integration of blockchains with management information systems

In the era of the fourth industrial revolution (Industry 4.0), many Management Information Systems (MIS) integrate real-time data collection and use technologies such as big data, machine learning, and cloud computing, to foster a wide range of creative innovations, business improvements, and new business models and processes. However, the integration of blockchain with MIS offers the blockchain trilemma of security, decentralisation and scalability. MIS are usually Web 2.0 clientserver applications that include the front end web systems and back end databases; while blockchain systems are Web 3.0 decentralised applications. MIS are usually private systems that a single party controls and manages; while blockchain systems are usually public, and any party can join and participate. This paper clarifies the key concepts and illustrates with figures, the implementation of public, private and consortium blockchains on the Ethereum platform. Ultimately, the paper presents a framework for building a private blockchain system on the public Ethereum blockchain. Then,integrating the Web 2.0 client-server applications that are commonly used in MIS with Web 3.0 decentralised blockchain applications

Drawing metro maps in concentric circles: A designer‐in‐the‐loop approach with visual examples

This article presents a proof-of-concept designer-in-the-loop schematic map drawing tool, based on the marriage of two approaches—manual and automated, which provides the technical interactivity of drawing tools between the user and the computer. We focus on concentric circle maps as opposed to the commonly used orthogonal mode representation, which is suggested by previous studies that it could promote better network learning. In comparison with existing methods, the proposed method is more compatible with the framework of effective map design from psychological and aesthetic perspectives, and a range of options can be provided in conjunction with users' preferences. We evaluated our approach on a set of iterations with case studies of Hong Kong metro with a group of three co-authors from the fields of geography, transport engineering, and education

Using Cognitive Work Analysis for Information System Design - a Dashboard for Visualising Liquidity

This paper presents the application of Cognitive Work Analysis (CWA) to create an Abstraction Hierarchy (AH) model that helps users to identify key functional relationships for managing financial systemic risk. Users may include investors, government agencies, policymakers, and financial institutions. The AH model will ultimately lead to an artefact that embeds visual analytics (the science of analytical reasoning facilitated by interactive interfaces) and combines automated analysis with dynamic interaction with the data. Based on the notion that companies with high leverage (total debt/equity) are more likely to become financially distressed than those with low leverage, our approach demonstrates how the CWA approach can be incorporated into a visual analytics system development methodology, and how the resultant prototype can be successfully applied to visualise macroprudential risk

Anti-PD1 does not improve pyroptosis induced by γδ T cells but promotes tumor regression in a pleural mesothelioma mouse model

IntroductionMesothelioma is an aggressive tumor in the pleural cavity that is difficult to treat. Diagnosis is usually late with minimal treatment options available for the patients and with unfavorable outcomes. However, recent advances in immunotherapy using γδ T cells may have potential against mesothelioma, given its ample tumoricidal and tumor-migratory properties could allow its infiltration to the widespread tumor mass. Thus, we hypothesize that Vδ2 T cells can perform cytotoxic activities against mesothelioma especially when combined with immune checkpoint blocker against PD-1.MethodsHuman Vδ2 T cells were expanded from peripheral blood mononuclear cells using Tetrakis‐pivaloyloxymethyl 2‐(thiazole‐2‐ylamino) ethylidene‐1,1‐bisphosphonate (PTA) plus IL-2 for 13 days, before used to test for cytotoxicity against mesothelioma cell lines. Mesothelioma-bearing mice was established by Intrapleural administration of mesothelioma cell lines to test for the efficacy of Vδ2 T cells plus anti-PD-1 antibody combination treatment. Pyroptosis was evaluated by cell morphology, western blot analysis, and ELISA experiments. Flow cytometry was used to examine expression of BTN2A1, BTN3A1, PD-L1, PD-L2 on mesothelioma cell lines. Immunofluorescence staining was performed to detect Vδ2 T cells post adoptive transfer and characteristics of pyroptosis in ex vivo mesothelioma tissue sections.ResultsIndeed, our data demonstrated that Vδ2 T cells killing mesothelioma can be enhanced by anti-PD-1 antibody in vitro, especially for high PD-1 expressing cells, and in vivo in the intrapleural mesothelioma mice model established by us. Adoptive transfer of Vδ2 T cells into these mice leads to tumor regression by 30-40% compared to control. Immunofluorescence of the tumor section confirmed infiltration of Vδ2 T cells into the tumor, especially to cells with BTN2A1 expression (a Vδ2 T cell activating molecule) despite PD-L1 co-localization. Interestingly, these cells co-expressed cleaved gasdermin D, suggesting that pyroptosis was induced by Vδ2 T cells. This was verified by Vδ2 T/mesothelioma co-culture experiments demonstrating membrane ballooning morphology, increased cleaved caspase-3 and gasdermin E, and upregulated IL-1β and IL-18.DiscussionVδ2 T cells plus anti-PD1 exhibited cytotoxicity against mesothelioma in vivo. However, we found no advantage for anti-PD-1 against PD-1 high expressing Vδ2 T cells in promoting pyroptosis. Taken together, our work demonstrated that Vδ2 T cells combined with anti-PD-1 antibody can be developed as a potential combination immunotherapy for mesothelioma

Making investment decisions on RFID technology: an evaluation of key adoption factors in construction firms

The importance of RFID technology is increasing as a means of enhancing productivity and efficiency, and reducing costs. The purpose of this research paper is to study the influence of technological, organizational, environmental, and innovation factors on the adoption of RFID technology by construction companies in Australia. With the growth of Australia's economy, in particular, the construction sector, the logistics departments in construction companies should pay attention to the adoption of more efficient technologies to provide better services for their customers. This paper provides a consolidated framework of RFID technology adoption based on studies on RFID technology adoption in particular from an IS perspective. The paper combines an integrated model of the Technology-Organization-Environment framework, the Diffusion of Innovation theory, and Actor-Network Theory to establish a more comprehensive innovation adoption framework for RFID technology. The data gathered to study the factors affecting the adoption of RFID technology are analysed from the results of a survey of construction companies in Australia, in which 297 Information Technology (IT) staff were participants in this research. The research results show that the factors which had a statistically significant and positive impact on the adoption of RFID services in construction companies were: relative advantage, compatibility, cost, expected benefits, top management support, external support and organization size. The findings from this research study have the potential to provide insights to firms seeking to make investment decisions on the adoption of RFID technology

Thermal comfort and energy performance of public rental housing under typical and near-extreme weather conditions in Hong Kong

© 2017 Elsevier B.V. Building performance evaluation is crucial for sustainable urban developments. In high-density cities, occupants suffer from poor living conditions due to building overheating, especially during increasingly frequent near-extreme summer conditions caused by climate change. To represent this situation, the summer reference year weather data was employed for building simulations using DesignBuilder. This study aims to evaluate the thermal comfort and energy consumption of four typical public rental housing (PRH) building types in Hong Kong. For free-running flats, results show generally higher air temperatures in the oldest PRH type (Slab) with a compact linear building form and the most sensitive response to outdoor temperature changes for another older PRH type (Trident) with a Y-shaped design, possibly owing to its high wall conductivity. Occupants in all building types experience a ???10% increase in the proportion of discomfort hours when compared to results for typical summer conditions, but overheating is the most severe in Slab type PRH. Following an initial assessment of the cooling energy usage, a simple sensitivity test was conducted to explore the potential energy savings by various passive design strategies, including shading and reducing the exposed cooled space. A cross-shaped building form also appears to be more energy efficient. These findings, complemented by further parametric analyses, may prove useful when designing buildings for climate change

A handbook for using elder academy as a platform of other learning experiences

This handbook will discuss how school syllabus, Other Learning Experiences (OLE) and Elder Academy (EA) can be integrated. It will provide some structures for schools as a reference and help develop a comprehensive learning plan. Besides, the handbook will mention different roles and responsibilities of stakeholders, as well as the suggestions and guidelines for assessment. The programs and activities in the “Elder Academy at Lingnan” will be taken as examples to demonstrate the guidelines. This can provide a better understanding of the operation mode of the integration between school curricula, OLE and EA. Hence, interested stakeholders can perform their own plans more systematically and effectively.https://commons.ln.edu.hk/osl_book/1000/thumbnail.jp

A comparative study on the indoor thermal comfort and energy consumption of typical public rental housing types under near-extreme summer conditions in Hong Kong

© 2017 The Authors. Published by Elsevier Ltd. Residents of the dense urban environment in Hong Kong suffer from poor living conditions due to building overheating, especially during near-extreme summer conditions. In this study, the thermal comfort and energy performance of typical public rental housing (PRH) building types were simulated using DesignBuilder. Results show that the oldest Slab type PRH, which has a compact building form, has the highest indoor air temperature, yet the lowest cooling energy demand. On the other hand, the Trident type PRH, with the largest external wall U-value, performs the worst overall and is the most responsive to outdoor temperature changes